针刺联合艾灸对慢性盆腔炎患者炎性反应指标及中医症候积分的影响

目的:探究针刺联合艾灸对气滞血瘀型慢性盆腔炎性患者炎性反应指标及中医症候积分的影响。方法:选取2017年3月至2019年3月安徽中医药大学第二附属医院收治的气滞血瘀型慢性盆腔炎性患者60例作为研究对象,将其按照随机数字表法分为观察组和对照组,每组30例。2组患者均行常规抗炎治疗,对照组在此基础上加用针刺治疗,观察组在对照组治疗基础上加用艾灸治疗,对比治疗前后2组白细胞计数、中医证候积分及不良反应情况。结果:观察组的临床治疗有效率明显优于对照组(P<0.05);分组治疗后观察组中医症候积分均明显低于对照组及治疗前(P<0.05);治疗后观察组RBC明显低于对照组和治疗前(P<0.05);治疗期间观察组不良反应发生率低于对照组,但差异无统计学意义(P>0.05)。结论:针刺联合艾灸可显著提高慢性盆腔炎性的治疗效果,改善患者中医证候、减轻炎性反应,且治疗安全性高,值得临床推广应用。     

"双固一通"艾灸法对糖尿病及糖尿病周围神经病变大鼠海马BDNF和NT-3蛋白的影响

目的观察“双固一通”艾灸法对糖尿病DM 及糖尿病周围神经病变(DPN)大鼠血糖及海马中神经营养因子(BDNF)和神经营养素-3(NT-3)蛋白的影响。方法75只雄性SD大鼠随机分为A组、B组、C组、D组和E组,每组15只。A组为正常对照组,不进行任何干预,B组为DM模型组,造模后不行艾灸干预;C组为DM艾灸治疗组,采用艾条悬灸;D组为DPN模型组,造模后不行艾灸干预;E组为DPN艾灸治疗组,采用艾条悬灸。于造模后72 h、4周治疗结束后和8周治疗结束后空腹尾静脉采血测血糖,于4周治疗结束后和8周治疗结束后,用免疫组化试验方法检测各组大鼠海马中BDNF和NT-3蛋白表达情况。结果B组、D组与A组血糖水平比较,差异有统计学意义(P<0.05),C组与B组比较,大鼠血糖水平降低(P<0.05);E组与D组比较,大鼠血糖水平降低(P<0.05)。B组、D组大鼠海马BDNF及NT-3免疫阳性神经元平均光密度值较A组明显减少(P<0.05);与B组比较,C组大鼠BDNF及NT-3免疫阳性神经元平均光密度值明显增加(P<0.05);与D组比较,E组大鼠BDNF及NT-3免疫阳性神经元平均光密度值明显增加(P<0.05)。结论“双固一通”艾灸法不仅可以起到明显的降糖效果,还可通过影响BDNF和NT-3蛋白的产生,保护糖尿病大鼠的感觉神经元,并对糖尿病及并发症周围神经病变起到治疗作用。     

至阳八阵穴隔附子饼灸治疗糖尿病胃轻瘫临床研究

目的观察至阳八阵穴隔附子饼灸治疗脾胃气虚型糖尿病胃轻瘫的疗效及对胃泌素(GAS)、胃动素(MTL)和血管活性肠肽(VIP)水平的影响。方法86例脾胃气虚型糖尿病胃轻瘫患者随机分为对照组和治疗组,每组43例。治疗组给予至阳八阵穴隔附子饼灸;对照组口服枸橼酸莫沙必利片。治疗12周后观察胃轻瘫主要症状指数量表症状积分改善情况、胃排空率及血清GAS、MTL、VIP水平。结果治疗组治疗后在胃轻瘫主要症状指数量表症状积分及胃排空率方面明显高于对照组,差异均有统计学意义(P<0.05)。治疗组治疗后血清GAS、MTL水平明显高于对照组,血清VIP水平明显低于对照组,差异均有统计学意义(P<0.05)。治疗组总有效率为90.7%,明显高于对照组的72.1%(P<0.05)。结论采用至阳八阵穴隔附子饼灸能快速促进糖尿病胃轻瘫患者胃功能的恢复,改善症状和体征,其作用机制可能与升高患者血清GAS和MTL水平,降低VIP水平有关。     

热敏灸小镇建设助力江西热敏灸产业发展的对策研究

近年来,江西资溪、丰城等地的实践探索表明,热敏灸小镇建设对于助推江西热敏灸产业发展具有十分重要的作用。然而,当前江西热敏灸小镇建设在标准、人才、组织、产品、服务等方面还存在诸多问题。为此,有必要在借鉴省外成功经验的基础上,从找准定位、培养人才、规范管理、健全标准、强化保障等五个方面进一步加强热敏灸小镇建设,助力江西热敏灸产业发展。     

Tableting properties of microcrystalline cellulose obtained from wheat straw measured with a single punch bench top tablet press

The objective of this work was to study the relation between the manufacturing conditions of microcrystalline cellulose (MCC), its physicochemical properties and its tableting behavior. Two different preparation procedures were used to produce MCC from wheat straw, utilizing an acid hydrolysis method, either using only sulfuric acid or combination of sulfuric and hydrochloric acid. The tableting behavior of obtained MCC samples and mixtures of MCC with ibuprofen was studied using a dynamic powder compaction analyzer. It was observed that some of the obtained MCC samples showed better flowing properties than commercially available Vivapur® PH101 and also very high values of tensile strength, solid fraction and elastic recovery. This can be linked with its good compaction behavior, but on the other hand it can cause problems with the disintegration of the tablets. In mixtures with ibuprofen, MCC samples showed lower values of tensile strength, while on the other hand elastic recovery did not seem to be much affected, still exhibiting very high values. According to the obtained results, it can be concluded that MCC obtained from the agricultural waste could have satisfactory properties for tablet preparation by the direct compression method. Further studies are needed to optimize process conditions in order to achieve better physicochemical characteristics, especially in terms of elastic recovery.     

艾尔巴韦/格拉瑞韦治疗慢性丙型肝炎患者疗效初步观察

目的 初步探讨应用艾尔巴韦/格拉瑞韦治疗慢性丙型肝炎(CHC)患者的疗效。方法 2017年3月~2018年3月仙桃市第一人民医院感染病科收治的CHC患者82例,被随机分为对照组41例和观察组41例,分别给予聚乙二醇干扰素-α联合利巴韦林治疗和艾尔巴韦/格拉瑞韦治疗,两组均连续治疗24周。采用RT- PCR法检测血清 HCV RNA,采用全基因序列测定法行病毒基因分型。比较两组早期病毒学应答(EVR)、治疗结束时病毒学应答(ETVR)和持续病毒学应答(SVR)。结果 在治疗结束时,观察组血清丙氨酸氨基转移酶(ALT)水平为(47.9±19.7)U/L,显著低于对照组【(63.5±21.2)U/L,P<0.05】,天冬氨酸氨基转移酶(AST)水平为(55.5±22.3)U/L,显著低于对照组【(81.3±25.8)U/L,P<0.05】;观察组EVR、ETVR和SVR分别为48.8%、63.4%和70.7%,与对照组的41.5%、53.7%和65.8%比,无统计学差异(P>0.05);18例观察组非HCV Ⅰ型感染者EVR、ETVR和SVR分别为88.9%、94.4%和88.9%,显著高于同组23例HCV Ⅰ型感染者(分别为52.2%、60.9%和52.2%, P<0.05),而与对照组15例非HCV Ⅰ型感染者比,无统计学差异(分别为86.7%、93.3%和73.3%, P>0.05);观察组SVR₁₂为87.8%(36/41),显著高于对照组的73.2%(30/41,P<0.05)。结论 应用直接抗病毒(DAA)药物艾尔巴韦/格拉瑞韦治疗CHC患者近期疗效达到,但远期疗效似优于标准治疗方案, 值得临床进一步验证。     

督脉灸联合香砂养胃丸治疗脾虚泄泻的临床观察

目的观察督脉灸联合香砂养胃丸治疗脾虚泄泻的临床疗效。方法将2018年3月—2019年3月在东营市垦利县人民医院确诊为脾虚泄泻的90例患者,按照随机数字表法分为对照组和观察组各45例。对照组采用香砂养胃丸治疗,观察组采用香砂养胃丸联合督脉灸治疗。两组治疗1个疗程后观察并比较疗效以及治疗前后各项中医证候积分变化情况。结果治疗后观察组总有效率为88.89%,高于对照组的57.87%,观察组各项中医证候积分均降低且低于对照组,两组各项指标差异均具有统计学意义(P<0.05)。结论督脉灸联合香砂养胃丸治疗脾虚泄泻疗效显著,能够有效改善患者临床症状。     

Estimating the daily intake of essential and nonessential elements from lamb m. longissimus thoracis et lumborum consumed by the population in Missouri (United States)

This paper estimated the daily intake of essential and nonessential elements from lamb muscle longissimus thoracis et lumborum (m. LTL) available to the population in Missouri. Missouri grain-finished (n = 36), Missouri grass-finished (n = 40) and imported New Zealand grass-finished (n = 40) lamb m. LTL were purchased and assayed for their element composition. Total mercury in samples was quantified by atomic absorption spectrometry and other elements were analyzed by inductively coupled plasma-optical emission spectrometry. Analysis of certified reference materials (DORM-2 and TORT-2) gave recovery rates ranging from 86 to 108% and 85 to 104%, respectively. The abundance of essential elements in Missouri grain-finished and Missouri grass-finished lamb m. LTL followed the order: Potassium > phosphorus > sodium > magnesium > calcium > zinc > iron. The order in the imported New Zealand grass-finished group was: Potassium > phosphorus > sodium > calcium > magnesium > zinc > iron. Since many variables lacked normality, non-parametric (Kruskal–Wallis) comparison test was performed and the results suggested no significant difference (P > 0.05) in element composition among the lamb m. LTL groups. The estimated daily intake of 14 elements from consumption of 100 g lamb m. LTL posed no hazard to consumers.     

新冠肺炎疫情下艾灸防治帕金森病的临床应用分析＊

帕金森病（Parkinson''s disease，PD）是仅次于阿尔茨海默病的世界第二大神经系统退行性疾病，随着老龄化社会的到来，PD患病率呈明显上升趋势。全球爆发的新型冠状病毒肺炎（简称新冠肺炎）是一种急性传染性疾病，严重威胁人们的身体健康和生命安全。PD患者大多为老年人且合并有基础疾病，体质普遍较弱，是新冠肺炎的易感人群，一旦染病则发展为重症的风险很高。中医艾灸疗法在治疗PD及防治疫病方面发挥了很好的辅助治疗效果。通督扶阳灸法联合强壮穴艾灸治疗，既可以帮助PD患者改善临床症状，延缓病情进展，又可以提高机体免疫功能，增强抗病能力而防治新冠肺炎。